Aerial forest spraying of the herbicide glyphosate became a concern near the Turtle Creek Watershed in 2017.
The reservoir supplies water to more than 100,000 in Greater Moncton.
Mayor Dawn Arnold says it's absolutely critical to protect the watershed and do whatever it takes to ensure there are no risks in that area.
"So how are we going to do that? We are in conversation with the province at the moment to figure that out. Whether it's declaring that area a conservation zone... maybe that's the way for it," she notes.
While Health Canada has deemed glyphosate safe to use as directed, the World Health Organization said in 2015 that it was probably carcinogenic to humans.
Provincial Environment Minister Serge Rouselle has said exposure to the herbicide poses no increased risk to New Brunswickers.